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SIAIS164018 hydrochloride

SIAIS164018 hydrochloride is a potent PROTAC degrader of ALK and EGFR, with IC50 values of 2.5 nM for ALK and 6.6 nM for the ALK G1202R mutant. It demonstrates robust anti-cancer activity in vitro by inhibiting cell migration and invasion, inducing G1 phase arrest, and promoting apoptosis, outperforming brigatinib in these assays.

Product Specifications

Field of Research

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Molecular Formula

C43H49Cl2N10O7P

Molecular Weight

919.79

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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