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ERD-3111

ERD-3111 (Compound 44) is a potent, orally bioavailable PROTAC that selectively degrades ERα with a DC50 of 0.5 nM. It demonstrates robust anti-tumor activity in vivo against both wild-type and ESR1-mutant ER+ breast cancer models, making it a valuable chemical probe for investigating endocrine resistance mechanisms.

Product Specifications

CAS Number

2832865-25-3

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Smiles

C (C (F) F) N1[C@@H] (C2=C (C3=C (C=C2) NN=C3) C[C@H]1C) C4=C (F) C=C (C=C4F) N5CCC6 (CC5) CCN (C (CN7CC=8C (C7) =CC9=C (C8) C (=O) N (C9=O) C%10C (=O) NC (=O) CC%10) =O) CC6

Molecular Formula

C45H46F4N8O5

Molecular Weight

854.89

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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