Perforin-IN-2

Perforin-IN-2 is a benzosulfonamide-based small molecule that potently inhibits perforin, showing an IC50 of 6.65 μM in vitro against Jurkat cells and efficacy in mitigating transplant rejection in allogeneic transplantation models in vivo. Its high plasma protein binding (99.8%) and required concentration for optimal activity make it a valuable research tool for immunology and transplantation studies.