Perforin-IN-2
Perforin-IN-2 is a benzosulfonamide-based small molecule that potently inhibits perforin, showing an IC50 of 6.65 μM in vitro against Jurkat cells and efficacy in mitigating transplant rejection in allogeneic transplantation models in vivo. Its high plasma protein binding (99.8%) and required concentration for optimal activity make it a valuable research tool for immunology and transplantation studies.
Product Specifications
CAS Number
1567836-70-7
Smiles
O=C1C=2C (=CC (C=3SC (=CC3) C=4C=C (NS (=O) (=O) C5=C (N (=O) =O) C=CC=C5) C=NC4) =CC2) CN1C
Molecular Formula
C24H18N4O5S2
Molecular Weight
506.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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