SN-38-CM2
SN-38-CM2 is a split esterase prodrug that rapidly converts to the active topoisomerase I inhibitor SN-38 (>95% in 5 minutes in vitro) . Its activation is triggered by protein-protein interactions, mediating cell death in models like MDA-MB-231 breast cancer cells, supporting research in targeted cancer therapy and prodrug development.
Product Specifications
CAS Number
2376127-86-3
Smiles
O (COC (=O) C1 (C) CC1) [C@@]2 (CC) C3=C (C (=O) N4C (=C3) C=5C (C4) =C (CC) C=6C (N5) =CC=C (OCOC (=O) C7 (C) CC7) C6) COC2=O
Molecular Formula
C34H36N2O9
Molecular Weight
616.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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