G36
G-36 is a cell-permeable nonsteroidal antagonist of the G protein-coupled estrogen receptor (GPER/GPR30), which selectively inhibits estrogen-mediated PI3K activation through GPER, rather than Erα. G-36 also inhibits estrogen-mediated calcium mobilization (IC50=112 nM) . G-36 is promising for research in the field of cancer[1][2].
Product Specifications
CAS Number
1392487-51-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/g36.html
Purity
99.35
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CC(C1=CC2=C(N[C@@H](C3=C(Br)C=C(OCO4)C4=C3)[C@]5([H])[C@@]2([H])C=CC5)C=C1)C
Molecular Formula
C22H22BrNO2
Molecular Weight
412.32
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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