MS432
MS432 is a PROTAC degrader that selectively targets MEK1 and MEK2 for ubiquitination and degradation via the VHL E3 ligase. This compound, derived from PD0325901, is a valuable chemical tool for investigating MEK/ERK pathway biology in both cellular and in vivo models of cancer and other diseases.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (N[C@@H] (C) C1=CC=C (C=C1) C2=C (N=CS2) C) [C@H]3C[C@@H] (O) CN3C ([C@@H] (NC (CCCCCCCCCCNCCCONC (C4=CC=C (C (F) =C4NC5=CC=C (C=C5F) I) F) =O) =O) C (C) (C) C) =O
Molecular Formula
C50H65F3IN7O6S
Molecular Weight
1076.06
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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