Tigloylgomisin H
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2) -ARE pathway, thus represents a potential liver cancer prevention agent[1].
Product Specifications
CAS Number
66069-55-4
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Natural Products
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tigloylgomisin-h.html
Solubility
10 mM in DMSO
Smiles
COC(C(OC)=C1)=C(OC(/C(C)=C/C)=O)C2=C1CC(C)C(C)(O)CC3=C2C(OC)=C(OC)C(OC)=C3
Molecular Formula
C28H36O8
Molecular Weight
500.58
References & Citations
[1]Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75 (12) :1314-8.|[2]Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75 (12) :1314-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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