BI8626
BI8626 is a small molecule inhibitor of the ubiquitin ligase HUWE1. It demonstrates protective effects in a spontaneous desiccation syndrome model using NOD/ShiLtj mice. In vitro, it reduces intracellular cholesterol, suppresses markers of T-cell activation like p-ZAP-70 and CD25, and inhibits CD4+ T-cell proliferation, making it a useful research tool for immunology and autoimmunity studies.
Product Specifications
CAS Number
1875036-75-1
Product Name Alternative
E1Enzyme, E1 Enzyme, E3 Enzyme, E2 Enzyme, E2Enzyme, E3Enzyme, BI 8626, BI8626, BI-8626, HUWE1
Field of Research
Protein Biochemistry
Purity
98.66% (May vary between batches)
Solubility
DMSO:60 mg/mL (136.2 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.54 mM)
Smiles
NCc1cccc (CNc2ncnc3c (ncnc23) N2CCN (Cc3ccccc3) CC2) c1
Molecular Formula
C25H28N8
Molecular Weight
440.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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