PROTAC Sirt2 Degrader-1
PROTAC Sirt2 Degrader-1 is a heterobifunctional molecule that selectively degrades Sirt2 by linking a potent Sirt2 inhibitor to a cereblon E3 ligase ligand. It exhibits high selectivity with an IC50 of 0.25 μM for Sirt2 over Sirt1/3. This tool compound is used in vitro and in vivo to study Sirt2's role in cancer, neurodegeneration, and other cellular processes.
Product Specifications
CAS Number
2098487-75-1
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Smiles
Cc1cc (C) nc (SCC (=O) Nc2ncc (Cc3cccc (OCc4cn (CCCCNC (=O) COc5cccc6C (=O) N (C7CCC (=O) NC7=O) C (=O) c56) nn4) c3) s2) n1
Molecular Formula
C40H40N10O8S2
Molecular Weight
852.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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