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PROTAC Sirt2 Degrader-1

PROTAC Sirt2 Degrader-1 is a heterobifunctional molecule that selectively degrades Sirt2 by linking a potent Sirt2 inhibitor to a cereblon E3 ligase ligand. It exhibits high selectivity with an IC50 of 0.25 μM for Sirt2 over Sirt1/3. This tool compound is used in vitro and in vivo to study Sirt2's role in cancer, neurodegeneration, and other cellular processes.

Product Specifications

CAS Number

2098487-75-1

Field of Research

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Smiles

Cc1cc (C) nc (SCC (=O) Nc2ncc (Cc3cccc (OCc4cn (CCCCNC (=O) COc5cccc6C (=O) N (C7CCC (=O) NC7=O) C (=O) c56) nn4) c3) s2) n1

Molecular Formula

C40H40N10O8S2

Molecular Weight

852.94

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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