1,1,1-Trifluoroethyl-PEG4-propargyl

This bifunctional linker, featuring a 1,1,1-trifluoroethyl group and a terminal alkyne, is a key reagent for constructing PROTAC molecules via click chemistry. Its PEG4 spacer enhances solubility and pharmacokinetics, facilitating the development of degraders for both in vitro and in vivo target validation studies.