(-) -5-HT2C agonist-3

(-) -5-HT2C agonist-3 (compound (-) -19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. (-) -5-HT2C agonist-3 can be used in antipsychotic research[1].

Product Specifications

CAS Number

[2104810-16-2]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/minus-5-ht2c-agonist-3.html

Purity

98.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(C=CC=C1)=C1CNC[C@H]2[C@H](C3=C(C=CC(F)=C3)OC)C2.[H]Cl

Molecular Formula

C19H23ClFNO2

Molecular Weight

351.84

References & Citations

[1]Guiping Zhang, et al. "Discovery of N-substituted (2-phenylcyclopropyl) methylamines as functionally selective serotonin 2C receptor agonists for potential use as antipsychotic medications." Journal of medicinal chemistry 60.14 (2017) : 6273-6288.