Cevipabulin fumarate
Product Specifications
UNSPSC Description
Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line[1][2].
Target Antigen
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cevipabulin_fumarate.html
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : 1.43 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C[C@@H](C(F)(F)F)NC1=C(C2=C(F)C=C(OCCCNC)C=C2F)C(Cl)=NC3=NC=NN13.O=C(O)/C=C/C(O)=O
Molecular Weight
580.89
References & Citations
[1]Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300.|[2]Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both DB01229-like and Leurocristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14949C/Cevipabulin-fumarate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14949C/Cevipabulin-fumarate-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
849550-67-0
Available Sizes
Curated Selection
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