BI-3663
BI-3663 is a potent and selective PROTAC degrader of PTK2/FAK, achieving degradation with an IC50 of 18 nM by recruiting cereblon E3 ligase. This molecule, derived from BI-4464 and pomalidomide, has demonstrated anti-cancer activity in cellular assays and is a valuable chemical probe for investigating FAK-dependent oncology and metastasis research.
Product Specifications
CAS Number
2341740-84-7
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (NCCOCCOCCOCCC (=O) NC1=CC=CC=2C (=O) N (C (=O) C12) C3C (=O) NC (=O) CC3) C4=CC=C (NC5=NC=C (C (=N5) OC6=CC=CC7=C6C (=O) CC7) C (F) (F) F) C (OC) =C4
Molecular Formula
C44H42F3N7O12
Molecular Weight
917.84
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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