Boc-Pip-alkyne-Ph-COOH

This alkyl/ether linker is a key component in synthesizing PROTACs like ARD-266, which potently degrades the androgen receptor (AR) in prostate cancer cell lines (e.g., LNCaP, VCaP) with DC50 values as low as 0.2 nM. It is a valuable tool for research in targeted protein degradation and oncology, supporting both in vitro and in vivo studies.