Boc-Pip-alkyne-Ph-COOH
This alkyl/ether linker is a key component in synthesizing PROTACs like ARD-266, which potently degrades the androgen receptor (AR) in prostate cancer cell lines (e.g., LNCaP, VCaP) with DC50 values as low as 0.2 nM. It is a valuable tool for research in targeted protein degradation and oncology, supporting both in vitro and in vivo studies.
Product Specifications
Field of Research
Musculoskeletal & Connective Tissue Research, Pharmacology & Drug Discovery
Smiles
OC (C1=CC=C (C#CC2CCN (C (OC (C) (C) C) =O) CC2) C=C1) =O
Molecular Formula
C19H23NO4
Molecular Weight
329.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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