DBCO-Val-Cit-OH
DBCO-Val-Cit-OH is a cleavable linker used in constructing antibody-drug conjugates (ADCs) for targeted cancer therapy. Its valine-citrulline dipeptide sequence is selectively cleaved by cathepsin B in the lysosomes of cancer cells, enabling the controlled release of cytotoxic payloads in both in vitro and in vivo research models.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (N1C2=C (C#CC3=C (C1) C=CC=C3) C=CC=C2) CCCCC (N[C@@H] (C (N[C@H] (C (O) =O) CCCNC (N) =O) =O) C (C) C) =O
Molecular Formula
C32H39N5O6
Molecular Weight
589.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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