K-Ras ligand-Linker Conjugate 1
This compound is a K-Ras ligand-linker conjugate designed for synthesizing PROTAC K-Ras Degraders. It facilitates the recruitment of E3 ligases like VHL and CRBN, enabling targeted protein degradation. The resulting degrader demonstrates ≥70% K-Ras degradation efficacy in SW1573 cell-based in vitro studies.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (N1CCOCCOCCOCCO[C@@H]2C[C@@H] (COC3=NC4=C (CCNC4) C (N5CCN (C (OCC6=CC=CC=C6) =O) [C@@H] (CC#N) C5) =N3) N (C) C2) C7=C (C=CC=C7) C1=O
Molecular Formula
C43H54N8O9
Molecular Weight
826.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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