K-Ras ligand-Linker Conjugate 3
K-Ras ligand-Linker Conjugate 3 is a bifunctional compound designed for synthesizing PROTAC degraders targeting K-Ras. It incorporates a K-Ras-binding ligand connected to a linker for E3 ligase recruitment. The resulting PROTAC K-Ras Degrader-1 demonstrates potent activity, achieving ≥70% degradation of K-Ras in cellular assays such as SW1573 cell lines.
Product Specifications
CAS Number
2378261-87-9
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
O (C[C@@H]1C[C@@H] (OCCOCCOCCOCCOS (=O) (=O) C2=CC=C (C) C=C2) CN1C) C3=NC (=C4C (CN (CC4) C=5C6=C (C=CC5) C=CC=C6) =N3) N7C[C@H] (CC#N) N (C (OC (C) (C) C) =O) CC7
Molecular Formula
C49H65N7O10S
Molecular Weight
944.15
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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