K-Ras ligand-Linker Conjugate 4

K-Ras ligand-Linker Conjugate 4 is a bifunctional compound designed for synthesizing PROTAC degraders targeting K-Ras. It incorporates a K-Ras-binding ligand connected to a linker capable of recruiting E3 ligases like VHL or CRBN. This conjugate serves as a key intermediate for developing potent degraders, such as PROTAC K-Ras Degrader-1, which has demonstrated ≥70% degradation efficacy in SW1573 cell studies.