K-Ras ligand-Linker Conjugate 5
K-Ras ligand-Linker Conjugate 5 is a bifunctional chemical precursor used to synthesize PROTAC K-Ras Degrader-1. This degrader demonstrates potent activity in vitro, achieving ≥70% K-Ras degradation in SW1573 cells, and is a key tool for targeted protein degradation research in oncology.
Product Specifications
CAS Number
2378261-85-7
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
CN1C[C@@H] (C[C@H]1COc1nc2CN (CCc2c (n1) N1CCN ([C@@H] (CC#N) C1) C (=O) OC (C) (C) C) c1cccc2ccccc12) OCCOCCOCCOCCO
Molecular Formula
C42H59N7O8
Molecular Weight
789.96
Storage Conditions
-20°C
Notes
For research use only.
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