MMAE-SMCC
MMAE-SMCC is a conjugation-ready chemical tool combining the potent microtubule inhibitor monomethyl auristatin E (MMAE) with the non-cleavable linker SMCC. This reagent is widely used in research for constructing stable antibody-drug conjugates (ADCs) to evaluate targeted cytotoxicity in both in vitro and in vivo cancer models.
Product Specifications
CAS Number
2021179-11-1
Product Name Alternative
DrugLinker Conjugates for ADC, DrugLinkerConjugatesforADC, Auristatin, MMAE SMCC, MMAESMCC, MMAE-SMCC
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
98.08% (May vary between batches)
Solubility
DMSO:120 mg/mL (105.22 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (3.51 mM)
Smiles
[C@H] ([C@H] (C (N[C@@H] ([C@@H] (O) C1=CC=CC=C1) C) =O) C) (OC) [C@]2 (N (C (C[C@H] ([C@@H] (N (C ([C@@H] (NC ([C@@H] (N (C (CCSC3C (=O) N (CC4CCC (C (ON5C (=O) CCC5=O) =O) CC4) C (=O) C3) =O) C) [C@@H] (C) C) =O) C (C) C) =O) C) [C@H] (CC) C) OC) =O) CCC2) [H]
Molecular Formula
C58H89N7O14S
Molecular Weight
1140.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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