N3-PEG3-vc-PAB-MMAE
This ADC drug-linker conjugate incorporates the potent tubulin inhibitor MMAE via a cleavable valine-citrulline linker and a triethylene glycol spacer. It is widely used in preclinical research for constructing antibody-drug conjugates to evaluate their antitumor efficacy in both in vitro cytotoxicity assays and in vivo xenograft models.
Product Specifications
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
CC[C@H] (C) [C@@H] ([C@@H] (CC (N1[C@@H] (CCC1) [C@@H] ([C@@H] (C) C (N[C@H] (C) [C@@H] (O) C2=CC=CC=C2) =O) OC) =O) OC) N (C ([C@H] (C (C) C) NC ([C@H] (C (C) C) N (C (OCC3=CC=C (NC ([C@H] (CCCNC (N) =O) NC ([C@H] (C (C) C) NC (CCOCCOCCOCCN=[N+]=[N-]) =O) =O) =O) C=C3) =O) C) =O) =O) C
Molecular Formula
C67H109N13O16
Molecular Weight
1352.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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