(S, R, S) -AHPC-C5-COOH
(S, R, S) -AHPC-C5-COOH (VH032-C5-COOH) is a VHL ligand-linker conjugate used for constructing PROTAC degraders. Its VH032 moiety potently inhibits the VHL:HIF-1α interaction (Kd = 185 nM), a target relevant in oncology and hypoxia research. This compound enables the study of targeted protein degradation in both cellular and in vivo models.
Product Specifications
CAS Number
2267282-19-7
Field of Research
Epigenetics & Chromatin, Metabolism Research, Pharmacology & Drug Discovery
Smiles
Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NCCCCCCC (O) =O) C (C) (C) C) cc1
Molecular Formula
C29H42N4O5S
Molecular Weight
558.73
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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