SD-36
SD-36 is a potent and selective STAT3 degrader (Kd ~50 nM) that suppresses STAT3 transcriptional activity. It exhibits antitumor effects in gliomas by inhibiting Mcl-1, leading to growth arrest and apoptosis in both cellular and animal models.
Product Specifications
CAS Number
2429877-44-9
Product Name Alternative
SD36, SD-36, SD 36, STAT3, STAT3:50 nM (Kd), Apoptosis, Cereblon
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (0.86 mM) ; DMSO:30 mg/mL (25.9 mM)
Smiles
C (N[C@H] (C (NC (C1=CC=CC=C1) C2=CC=CC=C2) =O) CCC (N) =O) (=O) [C@H]3N4[C@] (CC3) (CCN (C (CCCCCC#CC5=C6C (C (=O) N (C6) C7C (=O) NC (=O) CC7) =CC=C5) =O) C[C@H] (NC (=O) C8=CC=9C (N8) =CC=C (C (P (=O) (O) O) (F) F) C9) C4=O) [H]
Molecular Formula
C59H62F2N9O12P
Molecular Weight
1158.15
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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