SJFα
SJFα is a PROTAC molecule designed to selectively degrade p38α and p38δ isoforms. It functions by recruiting an E3 ubiquitin ligase to tag these kinases for proteasomal destruction. This tool compound is used in cancer research to study p38 signaling in both cellular and in vivo models.
Product Specifications
CAS Number
2254609-27-1
Product Name Alternative
Autophagy, p38δ, p38δ:299 nM (DC50), p38α, p38α:7.16 nM (DC50), p38MAPK, p38 MAPK, SJFα, SJF alpha, SJF α, SJFa, SJFalpha, PROTAC, VHL
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
95.25% (May vary between batches)
Solubility
DMSO:80 mg/mL (71.41 mM)
Smiles
C (NC1=CC (F) =C (OC=2C3=C (C=C (OCCCCOCCCCOCC (N[C@H] (C (=O) N4[C@H] (C (NCC5=CC=C (C=C5) C=6SC=NC6C) =O) C[C@@H] (O) C4) [C@] (C) (C) C) =O) C (OC) =C3) N=CC2) C=C1) (=O) C7 (C (NC8=CC=C (F) C=C8) =O) CC7
Molecular Formula
C59H67F2N7O11S
Molecular Weight
1120.27
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS8103815-01 0.1 mL
Recombinant Anti-MICB Antibody, Rabbit Monoclonal
Sign In for Pricing
View Details MBS8103815-02 5x 0.1 mL
Recombinant Anti-MICB Antibody, Rabbit Monoclonal
Sign In for Pricing
View Details