SNIPER (ABL) -019
SNIPER (ABL) -019 is a heterobifunctional degrader that conjugates the ABL inhibitor Dasatinib to the IAP ligand MV-1. It potently induces the degradation of BCR-ABL with a DC50 of 0.3 μM, providing a valuable chemical tool for targeted protein degradation research in chronic myeloid leukemia models, both in vitro and in vivo.
Product Specifications
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
CC1=C (NC (C2=CN=C (NC3=CC (N4CCN (C (COCCOCCOCCNC ([C@H] (C (C5=CC=CC=C5) C6=CC=CC=C6) NC ([C@H]7N (C ([C@@H] (NC ([C@H] (C) NC) =O) C8CCCCC8) =O) CCC7) =O) =O) =O) CC4) =NC (C) =N3) S2) =O) C (Cl) =CC=C1
Molecular Formula
C60H77ClN12O9S
Molecular Weight
1177.85
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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