SNIPER (ABL) -024
SNIPER (ABL) -024 is a heterobifunctional degrader that conjugates the ABL inhibitor GNF5 to an IAP ligand, inducing the degradation of BCR-ABL with a DC50 of 5 μM. This PROTAC-like molecule serves as a valuable chemical tool for targeted protein degradation research in chronic myeloid leukemia models, both in cellular and biochemical studies.
Product Specifications
CAS Number
2222355-77-1
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C ([C@@H] (NC ([C@@H] (NC) C) =O) C1CCCCC1) (=O) N2[C@@] (CCC2) (C3=NC (C (=O) C4=CC (OCCOCCOCCOCCNC (=O) C5=CC (=CC=C5) C=6C=C (NC7=CC=C (OC (F) (F) F) C=C7) N=CN6) =CC=C4) =CS3) [H]
Molecular Formula
C52H61F3N8O9S
Molecular Weight
1031.15
Storage Conditions
-20°C
Notes
For research use only.
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