SNIPER (ABL) -047
SNIPER (ABL) -047 is a heterobifunctional degrader that conjugates an ABL kinase inhibitor to an IAP ligand, inducing proteasomal degradation of BCR-ABL. It demonstrates potent activity in cellular models with a DC50 of 2 μM, providing a valuable chemical tool for targeted protein degradation research in oncology.
Product Specifications
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
CCN1CCN (CC2=C (C (F) (F) F) C=C (NC (C3=CC (C4=NC5=C (N=C (NC (COCCOCCOCCNC ([C@H] (C (C6=CC=CC=C6) C7=CC=CC=C7) NC ([C@H]8N (C ([C@@H] (NC ([C@H] (C) NC) =O) C9CCCCC9) =O) CCC8) =O) =O) =O) S5) C=C4) =CC=C3) =O) C=C2) CC1
Molecular Formula
C67H82F3N11O9S
Molecular Weight
1274.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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