SNIPER (ABL) -047
SNIPER (ABL) -047 is a heterobifunctional degrader that conjugates an ABL kinase inhibitor to an IAP ligand, inducing proteasomal degradation of BCR-ABL. It demonstrates potent activity in cellular models with a DC50 of 2 μM, providing a valuable chemical tool for targeted protein degradation research in oncology.
Product Specifications
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
CCN1CCN (CC2=C (C (F) (F) F) C=C (NC (C3=CC (C4=NC5=C (N=C (NC (COCCOCCOCCNC ([C@H] (C (C6=CC=CC=C6) C7=CC=CC=C7) NC ([C@H]8N (C ([C@@H] (NC ([C@H] (C) NC) =O) C9CCCCC9) =O) CCC8) =O) =O) =O) S5) C=C4) =CC=C3) =O) C=C2) CC1
Molecular Formula
C67H82F3N11O9S
Molecular Weight
1274.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
406552-01 50 µL
HIST1H3A (Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST)
Sign In for Pricing
View Details 406552-02 100 µL
HIST1H3A (Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST)
Sign In for Pricing
View Details MB10407-02 100 µL
Phospho-Presenilin 1 (Ser310) monoclonal antibody
Sign In for Pricing
View Details