SNIPER (ABL) -058
SNIPER (ABL) -058 is a heterobifunctional degrader that conjugates an Imatinib-based ABL binder to an IAP ligand, inducing degradation of BCR-ABL with a DC50 of 10 μM. This PROTAC-like molecule serves as a chemical tool for targeted protein degradation research in oncology, applicable in both cellular and biochemical studies of BCR-ABL-driven pathologies.
Product Specifications
CAS Number
2222354-61-0
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C ([C@@H] (NC ([C@@H] (NC) C) =O) C1CCCCC1) (=O) N2[C@@] (CCC2) (C3=NC (C (=O) C4=CC (OCCOCCOCCOCC (=O) N5CCN (CC6=CC=C (C (NC7=CC (NC=8N=C (C=CN8) C=9C=CC=NC9) =C (C) C=C7) =O) C=C6) CC5) =CC=C4) =CS3) [H]
Molecular Formula
C62H75N11O9S
Molecular Weight
1150.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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