SNIPER (ABL) -058

SNIPER (ABL) -058 is a heterobifunctional degrader that conjugates an Imatinib-based ABL binder to an IAP ligand, inducing degradation of BCR-ABL with a DC50 of 10 μM. This PROTAC-like molecule serves as a chemical tool for targeted protein degradation research in oncology, applicable in both cellular and biochemical studies of BCR-ABL-driven pathologies.

Product Specifications

CAS Number

2222354-61-0

Field of Research

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Smiles

C ([C@@H] (NC ([C@@H] (NC) C) =O) C1CCCCC1) (=O) N2[C@@] (CCC2) (C3=NC (C (=O) C4=CC (OCCOCCOCCOCC (=O) N5CCN (CC6=CC=C (C (NC7=CC (NC=8N=C (C=CN8) C=9C=CC=NC9) =C (C) C=C7) =O) C=C6) CC5) =CC=C4) =CS3) [H]

Molecular Formula

C62H75N11O9S

Molecular Weight

1150.39

Storage Conditions

-20°C

Notes

For research use only.

SNIPER (ABL) -058

Product Specifications

CAS Number

Field of Research

Smiles

Molecular Formula

Molecular Weight

Storage Conditions

Notes

Available Sizes

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