SNIPER (ER) -87
SNIPER (ER) -87 is a heterobifunctional degrader that links an IAP ligand to 4-hydroxytamoxifen, selectively recruiting XIAP to ubiquitinate and degrade ERα (IC50 = 0.097 μM) . This PROTAC-like molecule is a valuable chemical tool for studying targeted protein degradation in ERα-positive breast cancer models, both in vitro and in vivo.
Product Specifications
CAS Number
2222354-91-6
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
[H][C@]1 (CCCN1C (=O) [C@@H] (NC (=O) [C@H] (C) NC) C1CCCCC1) c1nc (cs1) C (=O) c1cccc (OCCOCCOCCOCC (=O) N (C) CCOc2ccc (cc2) C (=C (CC) c2ccccc2) c2ccc (O) cc2) c1 |w:58.61|
Molecular Formula
C59H73N5O10S
Molecular Weight
1044.32
Storage Conditions
-20°C
Notes
For research use only.
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