MAC glucuronide α-hydroxy lactone-linked SN-38
This cytotoxic drug linker incorporates a stabilized lactone form of the SN-38 metabolite, a potent topoisomerase I inhibitor. It demonstrates in vitro efficacy against hematological cancer cell lines such as L540cy and Ramos, with IC50 values of 99 and 105 ng/mL, respectively. This compound is a valuable tool for developing antibody-drug conjugates (ADCs) and studying targeted cancer therapies.
Product Specifications
CAS Number
2246380-70-9
Field of Research
Pharmacology & Drug Discovery
Smiles
O=C1N2C (C=3C (C2) =C (CC) C=4C (N3) =CC=C (O) C4) =CC5=C1COC (=O) [C@]5 (OCN (C (OCC6=CC (NC (CN (C (CCN7C (=O) C=CC7=O) =O) C) =O) =C (O[C@@H]8O[C@H] (C (O) =O) [C@@H] (O) [C@H] (O) [C@H]8O) C=C6) =O) CCS (C) (=O) =O) CC
Molecular Formula
C50H54N6O20S
Molecular Weight
1091.06
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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