PF-06807656
PF-06807656 is a potent and selective ROMK inhibitor with an IC50 of 160 nM in Tl+ flux assays. Its activity is maintained against the N171D pore mutant, which typically confers resistance to other inhibitors. This compound is a valuable pharmacological tool for studying renal physiology and blood pressure regulation in both in vitro and in vivo research contexts.
Product Specifications
Smiles
O=C (NC (C1=NN (C) N=C1) C) C2=CC (S (=O) (NC3=CC=C (Cl) C=C3) =O) =C (OC) C=C2
Molecular Formula
C19H20ClN5O4S
Molecular Weight
449.91
Storage Conditions
-20°C
Notes
For research use only.
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