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PF-06807656

PF-06807656 is a potent and selective ROMK inhibitor with an IC50 of 160 nM in Tl+ flux assays. Its activity is maintained against the N171D pore mutant, which typically confers resistance to other inhibitors. This compound is a valuable pharmacological tool for studying renal physiology and blood pressure regulation in both in vitro and in vivo research contexts.

Product Specifications

Smiles

O=C (NC (C1=NN (C) N=C1) C) C2=CC (S (=O) (NC3=CC=C (Cl) C=C3) =O) =C (OC) C=C2

Molecular Formula

C19H20ClN5O4S

Molecular Weight

449.91

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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