Danusertib
Danusertib is a pyrrolo-pyrazole and aurora kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively.
Product Specifications
CAS Number
827318-97-8
Product Name Alternative
PHA-739358
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aurora Kinase; Autophagy
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Danusertib.html
Purity
99.44
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1CC2=C(NN=C2NC(C3=CC=C(N4CCN(CC4)C)C=C3)=O)C1)[C@@H](C5=CC=CC=C5)OC
Molecular Formula
C26H30N6O3
Molecular Weight
474.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Zi D, et al. Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells. Int J Mol Sci. 2015 Nov 13;16 (11) :27228-51.|[2]Gontarewicz A, et al. Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I. Blood. 2008 Apr 15;111 (8) :4355-64.|[3]Fraedrich K, et al. Targeting Aurora Kinases with Danusertib (PHA-739358) Inhibits Growth of Liver Metastases from Gastroenteropancreatic Neuroendocrine Tumors in an Orthotopic Xenograft Model. Clin Cancer Res. 2012 Sep 1;18 (17) :4621-32. Epub 2012 Jul 2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Aurora A; Aurora B; Aurora C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS2070124-01 0.1 mL
APC/CY7-Linked Polyclonal Antibody to Hedgehog Homolog, Desert (DHH)
Sign In for Pricing
View Details MBS2070124-02 0.2 mL
APC/CY7-Linked Polyclonal Antibody to Hedgehog Homolog, Desert (DHH)
Sign In for Pricing
View Details MBS2070124-03 0.5 mL
APC/CY7-Linked Polyclonal Antibody to Hedgehog Homolog, Desert (DHH)
Sign In for Pricing
View Details MBS2070124-04 1 mL
APC/CY7-Linked Polyclonal Antibody to Hedgehog Homolog, Desert (DHH)
Sign In for Pricing
View Details MBS2070124-05 5 mL
APC/CY7-Linked Polyclonal Antibody to Hedgehog Homolog, Desert (DHH)
Sign In for Pricing
View Details MBS2070124-06 5x 5 mL
APC/CY7-Linked Polyclonal Antibody to Hedgehog Homolog, Desert (DHH)
Sign In for Pricing
View Details