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A 83586C

A-83586C is a Streptomyces-derived depsipeptide antibiotic with potent in vitro activity against Gram-positive bacteria. This compound is a research tool that potently inhibits β-catenin/TCF4 signaling and E2F-mediated transcription in cancer cells, downregulating targets like osteopontin and E2F1 while modulating retinoblastoma protein phosphorylation. Its mechanisms support investigations in oncology, particularly in Wnt signaling and cell cycle pathways.

Product Specifications

CAS Number

116364-81-9

Field of Research

Infectious Disease & Virology

Smiles

[C@@] (C (N[C@H]1[C@H] (C (C) C) OC (=O) [C@@] ([C@H] (C) O) (NC (=O) [C@]2 (N (C (=O) [C@@H] (C) N (C) C (=O) [C@H] (C) N (O) C (=O) [C@@]3 (N (C1=O) NCCC3) [H]) NCCC2) [H]) [H]) =O) (CC) (O) [C@]4 (O) O[C@H] (\C (=C\[C@@H] (C (/C (=C/C) /C) =O) C) \C) [C@@H] (C) CC4

Molecular Formula

C47H76N8O14

Molecular Weight

977.15

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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