ARD-69

ARD-69 is a potent PROTAC degrader of the Androgen Receptor (AR) for prostate cancer research. It achieves DC50 values in the low nanomolar range in AR+ cell lines like LNCaP and VCaP, reducing AR protein >95% and suppressing AR-driven gene expression. This molecule is a valuable tool for investigating targeted protein degradation in both in vitro and in vivo models of castration-resistant prostate cancer.

Product Specifications

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Smiles

O=C ([C@H]1N (C ([C@@H] (NC (C2 (F) CC2) =O) C (C) (C) C) =O) C[C@H] (O) C1) N[C@H] (C3=CC=C (C4=C (C) N=CS4) C=C3) CC (N5CCC (N6CCC (C#CC7=CC=C (C (N[C@H]8C (C) (C) [C@H] (OC9=CC=C (C#N) C (Cl) =C9) C8 (C) C) =O) C=C7) CC6) CC5) =O