VU0463271

VU0463271 is a selective KCC2 antagonist, with an IC50 of 61 nM.

Product Specifications

CAS Number

[1391737-01-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/VU0463271.html

Concentration

10mM

Purity

99.77

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N(C1CC1)C2=NC(C)=CS2)CSC3=NN=C(C4=CC=CC=C4)C=C3

Molecular Formula

C19H18N4OS2

Molecular Weight

382.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Delpire E, et al. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett. 2012 Jul 15;22 (14) :4532-5.|[2]Rui Chen, et al. Functional Coupling of K +-Cl - Cotransporter (KCC) to GABA-Gated Cl - Channels in the Central Nervous System of Drosophila melanogaster Leads to Altered Drug Sensitivities. ACS Chem Neurosci. 2019 Jun 19;10 (6) :2765-2776.