TRPV1 antagonist 7
TRPV1 antagonist 7 (Compound 36) is a selective TRPV1 antagonist that effectively blocks capsaicin activation (IC50=2.31 nM) . TRPV1 antagonist 7 can be used in analgesic research[1].
Product Specifications
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trpv1-antagonist-7.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC(C2=C(CNC(NC3=CC=CC(N4)=C3OCC4=O)=O)SC(C(C)(C)C)=N2)=C1
Molecular Formula
C23H23ClN4O3S
Molecular Weight
470.97
References & Citations
[1]Huang G, et al. Discovery of N- (1,4-Benzoxazin-3-one) urea analogs as Mode-Selective TRPV1 antagonists. Bioorg Med Chem Lett. 2024 Apr 6:129735.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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