2-MeS-ADP (trisodium)
2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3].
Product Specifications
CAS Number
[475193-31-8]
Product Name Alternative
2-Methylthioadenosine diphosphate (trisodium) ; 2-Methylthio-ADP (trisodium)
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-mes-adp-trisodium.html
Concentration
10 mM * 185 μL in Water
Purity
99.90
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O
Molecular Formula
C11H14N5Na3O10P2S
Molecular Weight
539.24
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y12 Receptor; P2Y13 Receptor
Available Sizes
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