JH-IX-179
JH-IX-179 is a potent and highly selective type I ATP-competitive inhibitor of FLT3, including D835Y and ITD mutants. It demonstrates minimal serum protein binding and effectively blocks FLT3 autophosphorylation and downstream signaling. This profile supports its utility in preclinical research for investigating FLT3-driven pathologies, such as acute myeloid leukemia, in both cellular and animal models.
Product Specifications
Smiles
O=C1C2=C (NC3=C2C=CC (C4=CNN=C4) =C3) C5=C1C=CC (C6=CN (CCCN (C) C) N=C6) =C5
Molecular Formula
C26H24N6O
Molecular Weight
436.52
Storage Conditions
-20°C
Notes
For research use only.
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