KI696 isomer

KI696 isomer is the less active isomer of KI696 (HY-101140) . KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction[1].

Product Specifications

CAS Number

[1799974-69-8]

UNSPSC

12352005

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ki696-isomer.html

Purity

99.32

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

COC1=C(N2C)C(N=N2)=CC([C@@H](C3=CC(CN(C[C@H]4C)S(=O)(C5=CC=CC=C5O4)=O)=C(C)C=C3)CC(O)=O)=C1

Molecular Formula

C28H30N4O6S

Molecular Weight

550.63

References & Citations

[1]Davies TG, et al. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J Med Chem. 2016 Apr 28;59 (8) :3991-4006.