Tricarballylic acid

Tricarballylic acid is an orally active compound that can be produced by rumen microorganisms and has the activity of chelating magnesium. Tricarballylic acid is also a competitive inhibitor of aconitate hydratase, with a Ki value of 0.52 mM. Tricarballylic acid can inhibit the oxidation of acetate in the citric acid cycle and can be used in the research of ruminant tissue metabolism and grass tetany syndrome. In addition, Tricarballylic acid can be used to synthesize specific complexes and produce plasticizers[1][2][3][4].

Product Specifications

CAS Number

[99-14-9]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; Mitochondrial Metabolism

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tricarballylic-acid.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(CC(C(O)=O)CC(O)=O)O

Molecular Formula

C6H8O6

Molecular Weight

176.12

Precautions

H315, H319, H335

References & Citations

[1]Russell JB, et al. Production of tricarballylic acid by rumen microorganisms and its potential toxicity in ruminant tissue metabolism. Br J Nutr. 1986 Jul;56 (1) :153-62.|[2]Vlahou I, et al. Zinc complexes with tricarballylic acid and Lewis bases with zero-and two-dimensional structures. Inorganica chimica acta, 2006, 359 (11) : 3540-3548.|[3]Magne F C, et al. Plasticizers from aconitic and tricarballylic acids. Industrial & Engineering Chemistry, 1953, 45 (7) : 1546-1547.|[4]Schwartz R, et al. Effect of tricarballylic acid, a nonmetabolizable rumen fermentation product of trans-aconitic acid, on Mg, Ca and Zn utilization of rats. J Nutr. 1988 Feb;118 (2) :183-8.