Benzquinamide (hydrochloride)
Product Specifications
UNSPSC Description
Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells[1][2].
Target Antigen
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/benzquinamide-hydrochloride.html
Purity
99.14
Solubility
10 mM in DMSO|DMSO : 55 mg/mL (ultrasonic;warming)
Smiles
O=C(C1CN2CCC3=CC(OC)=C(OC)C=C3C2CC1OC(C)=O)N(CC)CC.[H]Cl
Molecular Weight
440.96
References & Citations
[1]Elisabet Gregori-Puigjané, et al. Identifying mechanism-of-action targets for drugs and probes. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28): 11178-11183.|[2]Mazzanti R, et al. Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells. Oncol Res. 1992;4(8-9):359-65.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-U00244A/Benzquinamide-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-U00244A/Benzquinamide-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
113-69-9
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