Benzquinamide (hydrochloride)

Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells[1][2].

Product Specifications

CAS Number

[113-69-9]

Product Name Alternative

P2647 (hydrochloride) ; BZQ (hydrochloride) ; Benzoquinamide (hydrochloride)

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/benzquinamide-hydrochloride.html

Purity

99.14

Solubility

10 mM in DMSO

Smiles

O=C(C1CN2CCC3=CC(OC)=C(OC)C=C3C2CC1OC(C)=O)N(CC)CC.[H]Cl

Molecular Formula

C22H33ClN2O5

Molecular Weight

440.96

References & Citations

[1]Elisabet Gregori-Puigjané, et al. Identifying mechanism-of-action targets for drugs and probes. Proc Natl Acad Sci U S A. 2012 Jul 10; 109 (28) : 11178-11183.|[2]Mazzanti R, et al. Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells. Oncol Res. 1992;4 (8-9) :359-65.