CRIPGBM (chloride)

CRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs) . cRIPGBM (chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce caspase 1-dependent apoptosis. cRIPGBM (chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of RIPK2/caspase 1 (proapoptotic complex) . cRIPGBM (chloride) exerts potent anti-tumor activity in vivo in animal models[1].

Product Specifications

CAS Number

[2361988-77-2]

Product Name Alternative

(1S,3R)-RSL3

UNSPSC

12352005

Hazard Statement

H317, H320, H350, H373, H410

Target

Apoptosis; Caspase; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cripgbm-chloride.html

Purity

99.82

Solubility

DMSO : 25 mg/mL (ultrasonic) |DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2[N+](CC3=CC=C(F)C=C3)=C(C)N1CC4=CC=CC=C4)C5=C(C=CC=C5)C2=O.[Cl-]

Molecular Formula

C26H20ClFN2O2

Molecular Weight

446.90

Precautions

H317, H320, H350, H373, H410

References & Citations

[1]Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116 (13) :6435-6440.