Psammaplin A

Psammaplin A is a potent and selective dual inhibitor of HDAC and DNMT enzymes, notably inhibiting DAC1 with an IC50 of 0.9 nM. This marine-derived compound exhibits antimicrobial activity against Gram-positive bacteria and demonstrates antitumor properties through mechanisms including DNA synthesis and gyrase inhibition, supporting its use in epigenetic and cancer research.