β-Apo-13-carotenone
β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.
Product Specifications
CAS Number
17974-57-1
Product Name Alternative
D'Orenone
UNSPSC
12352211
Hazard Statement
H317, H319, H360, H413
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/_beta_-Apo-13-carotenone.html
Purity
97.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)=O
Molecular Formula
C18H26O
Molecular Weight
258.40
Precautions
H317, H319, H360, H413
References & Citations
[1]Eroglu A, et al. The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα. Arch Biochem Biophys. 2010 Dec 1;504 (1) :11-6.|[2]Sun J, et al. β-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor. J Biol Chem. 2014 Nov 28;289 (48) :33118-24.|[3]Wang CX, et al. Actions of β-apo-carotenoids in differentiating cells: differential effects in P19 cells and 3T3-L1 adipocytes. Arch Biochem Biophys. 2015 Apr 15;572:2-10.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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