β-Apo-13-carotenone

β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.

Product Specifications

CAS Number

[17974-57-1]

Product Name Alternative

D'Orenone

UNSPSC

12352211

Hazard Statement

H317, H319, H360, H413

Target

RAR/RXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/_beta_-Apo-13-carotenone.html

Purity

97.39

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)=O

Molecular Formula

C18H26O

Molecular Weight

258.40

Precautions

H317, H319, H360, H413

References & Citations

[1]Eroglu A, et al. The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα. Arch Biochem Biophys. 2010 Dec 1;504 (1) :11-6.|[2]Sun J, et al. β-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor. J Biol Chem. 2014 Nov 28;289 (48) :33118-24.|[3]Wang CX, et al. Actions of β-apo-carotenoids in differentiating cells: differential effects in P19 cells and 3T3-L1 adipocytes. Arch Biochem Biophys. 2015 Apr 15;572:2-10.